Coconut Oil Studies - Other Health Concerns involving VCO and MCT Oil

17. 中鎖脂肪酸でできる、その他の健康効果とは?

1. バージンココナツオイル補充の抗酸化および抗炎症効果は、ラットに於いて抗癌剤メトトレキセートの急性化学療法の酸化的腎毒性を無効にします。

Antioxidant and anti-inflammatory effects of virgin coconut oil supplementation abrogate acute chemotherapy oxidative nephrotoxicity induced by anticancer drug methotrexate in rats.


2. Kerabalaの抗炎症および抗酸化効果:バージンココナッツオイルからの付加価値の高いアーユルヴェーダ製剤は、アジュバント誘発性関節炎の発病を阻害します。

Anti-inflammatory and antioxidant effect of Kerabala: a value-added ayurvedic formulation from virgin coconut oil inhibits pathogenesis in adjuvant-induced arthritis.




現在の研究は、カラゲナン誘発急性およびアジュバント誘導慢性実験モデルにおけるCBの抗炎症作用を評価するために行った。 5mg / kg体重は、カラゲナンモデルからの強力な用量であることが見出され、アジュバント誘発性慢性関節炎モデルにおけるその効果を評価した。


ヘモグロビン(HB)カウント、ESR、WBCカウント、血漿CRPレベルなどの血液学的パラメーターを分析した。 RT-PCRにより、シクロオキシゲナーゼ-2(COX-2)、誘導性酸化窒素シンターゼ(iNOS)、腫瘍壊死因子α(TNF-α)およびインターロイキン6(IL-6)発現のような炎症マーカーを評価した。





COX-2、iNOS、TNF-αおよびIL-6のような炎症マーカーのアップレギュレートされた遺伝子レベルの発現は、CBの投与によってダウンレギュレーションされた。 MMP-2およびMMP-9発現は、CB投与によって有意に低下した。






Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases.

This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil.

The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-induced acute and adjuvant-induced chronic experimental models. 5 mg/kg bwt was found to be potent dose from carrageenan model and evaluated its effect in adjuvant-induced chronic arthritic model.

The antioxidant assays like SOD, catalase, glutathione peroxidase, lipid peroxidation product, nitrate level and GSH were measured in paw tissue.

Hematological parameters like hemoglobin (HB) count, ESR, WBC count, plasma CRP levels were analyzed. By RT-PCR, the inflammatory markers like cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) expressions were evaluated.

The extracellular matrix proteins like MMP-2 and MMP-9 were determined by zymography and its expression by western blotting.

Histopathology and cytology of paw tissue and synovium were analyzed.

The result indicated that there was a significant increment in the levels of antioxidant enzymes on CB administration.

The hematological markers such as ESR, WBC and plasma CRP levels were reduced by CB treatment and it also increases the HB level.

The upregulated gene level expressions of inflammatory markers like COX-2, iNOS, TNF-α and IL-6 were down regulated by administration of CB. MMP-2 and MMP-9 expression significantly reduced by CB administration.

Massive influx of inflammatory cell infiltration, proliferative collagen in histological analysis of paw tissue of arthritic rat was decreased by CB administration.

Synovial cytology of CB administrated group shows reduced number of reactive mesothelial cells and synovial inflammatory cells.

This current study shows that ayurvedic drug CB has an antioxidant, anti-inflammatory and anti-arthritic activity in experimental arthritic model.

CB as an anti-arthritic drug has beneficial effect for treating inflammation, tissue damage and pain associated with arthritis.

3. マレーシアで広く使用されている発酵ヴァージンココナッツオイルの安全性評価:慢性毒性研究および活性成分のSAR分析。

Safety assessment of widely used fermented virgin coconut oil (Cocos nucifera) in Malaysia: Chronic toxicity studies and SAR analysis of the active components.

4. ココナッツオイル抽出物は、抗レトロウイルス薬によるアジュバント治療後の精巣損傷を軽減します。

Coconut Oil Extract Mitigates Testicular Injury Following Adjuvant Treatment with Antiretroviral Drugs.

5. ココナッツオイルとパームオイルの栄養、健康、国家発展の役割:レビュー。

Coconut oil and palm oil's role in nutrition, health and national development: A review.









Coconut and palm oils which were the major sources of dietary fats for centuries in most of West Africa have been branded as unhealthy highly saturated fats.

Their consumption has been peddled to supposedly raise the level of blood cholesterol, thereby increasing the risk of coronary heart disease.

This adverse view has led to a reduction in their consumption in West Africa and they have been substituted for imported vegetable oils.

Recent information however, indicates some beneficial effects of these oils particularly their roles in nutrition, health and national development.

There is the need for a better understanding of their effects on health, nutritional status and national development.

This paper therefore attempts to review the roles which coconut and palm oils play in these respects in developing countries, as a means of advocating for a return to their use in local diets.

6. ラウリン酸に富んだ中鎖トリグリセリドは、調理用途において他の油に代わることができ、限られた病原性を有する可能性がある。

Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity.











Recently, medium-chain triglycerides (MCTs) containing a large fraction of lauric acid (LA) (C12)-about 30%-have been introduced commercially for use in salad oils and in cooking applications.

As compared to the long-chain fatty acids found in other cooking oils, the medium-chain fats in MCTs are far less likely to be stored in adipose tissue, do not give rise to 'ectopic fat' metabolites that promote insulin resistance and inflammation, and may be less likely to activate macrophages.

When ingested, medium-chain fatty acids are rapidly oxidised in hepatic mitochondria; the resulting glut of acetyl-coenzyme A drives ketone body production and also provokes a thermogenic response.

Hence, studies in animals and humans indicate that MCT ingestion is less obesogenic than comparable intakes of longer chain oils.

Although LA tends to raise serum cholesterol, it has a more substantial impact on high density lipoprotein (HDL) than low density lipoprotein (LDL) in this regard, such that the ratio of total cholesterol to HDL cholesterol decreases.

LA constitutes about 50% of the fatty acid content of coconut oil; south Asian and Oceanic societies which use coconut oil as their primary source of dietary fat tend to be at low cardiovascular risk.

Since ketone bodies can exert neuroprotective effects, the moderate ketosis induced by regular MCT ingestion may have neuroprotective potential.

As compared to traditional MCTs featuring C6-C10, laurate-rich MCTs are more feasible for use in moderate-temperature frying and tend to produce a lower but more sustained pattern of blood ketone elevation owing to the more gradual hepatic oxidation of ingested laurate.

7. バージンココナッツオイルの補給は、マウスにおけるシクロホスファミド誘発全身毒性を改善します。

Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.


8. ココナッツオイルの補給と運動は、高血圧ラットに於いて、圧反射感受性と酸化ストレスを改善します。

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats.

9. パイロット研究:ウサギの眼の再湿潤剤としてのバージンココナッツオイルの有効性

A pilot study: the efficacy of virgin coconut oil as ocular rewetting agent on rabbit eyes.

wetting agent《化学》湿潤剤

10. アルミニウムリン化物中毒:特定の解毒剤が存在しない場合の対症療法の可能な役割

Aluminum phosphide poisoning: Possible role of supportive measures in the absence of specific antidote.

supportive measures 対症療法

11. バージンココナッツオイルから分離したポリフェノールは、抗酸化作用および抗炎症作用を介してラットのアジュバント誘発性関節炎を抑制します。

Polyphenolics isolated from virgin coconut oil inhibits adjuvant induced arthritis in rats through antioxidant and anti-inflammatory action.

12. ラットの酸化ストレス改善に、抗酸化状態およびパラオキソナーゼ1活性に関するバージンココナッツオイルが豊富な食品効果について - 比較研究。

Effect of virgin coconut oil enriched diet on the antioxidant status and paraoxonase 1 activity in ameliorating the oxidative stress in rats - a comparative study.

パラオキソナーゼ(paraoxonase: PON-1):脂質酸化物(lipid peroxides)を分解することにより、リポ蛋白の酸化保護作用を示す抗酸化酵素です。 PON-1はカルシウム依存性の糖蛋白であり、血液中においてHDL(High density lipoprotein)のアポリポ蛋白A1に結合して存在します。

13. 脂肪酸の摂取は、乳牛の成長と免疫を変化させます。

Fatty acid intake alters growth and immunity in milk-fed calves.


本研究の目的は、市販の酪酸、ココナッツオイル、亜麻仁油のブレンドであるNeoTec4(Provimi North America、Brookville、OH)に牛乳の代替品(MR)を補給する効果を、子牛の成長、効率、および免疫機能の指標を含む。

試験1aでは、48頭のオスのホルスタイン牛に動物脂肪のみを含む対照MRまたは自由選択スターターとともにNeoTec4(治療)を与えた同じMRを与えた。 MR(28.7%の粗タンパク質、15.6%の脂肪)は、平均1kgの乾物(DM)/ dで給餌された。



MR(22.8%粗タンパク質、18.9%脂肪)は平均1kgのDM / dで給餌された。スターターは供給されなかった。試験1aでは、NeoTec4は平均一日増加量、飼料摂取量、飼料効率を改善し、子ウシがスクワウアーを経験した日数を減少させ、クロストリジウム病の治療を減少させた。







The aim of the present study was to determine the effect of supplementing milk replacer (MR) with NeoTec4 (Provimi North America, Brookville, OH), a commercially available blend of butyric acid, coconut oil, and flax oil, on calf growth, efficiency, and indices of immune function.

In trial 1a, 48 male Holstein calves were fed either a control MR that contained only animal fat or the same MR with NeoTec4 (treatment) along with free-choice starter. The MR (28.7% crude protein, 15.6% fat) was fed at an average of 1 kg of dry matter (DM)/d.

In trial 1b, weaned calves from trial 1a were all fed dry starter for 28 d without NeoTec4 (phase 1), and then half the calves were fed NeoTec4 for 28 d (phase 2).

In trial 2, 40 male Holstein calves were fed a control MR with lard, coconut oil, and soy lecithin or the same MR supplemented with NeoTec4 (treatment).

The MR (22.8% crude protein, 18.9% fat) was fed at an average of 1 kg of DM/d; no starter was fed. In trial 1a, NeoTec4 improved average daily gain, feed intake, and feed efficiency, reduced the number of days that calves experienced scours, and reduced the medical treatments for clostridium sickness.

In trials 1a and 2, NeoTec4 altered the inflammatory response to vaccination with Pasteurella at 5 wk of age and to challenge with Salmonella toxin at less than 2 wk of age (fed NeoTec4 for 6 d), as observed by reduced hyperthermia and hypophagia, and altered the tumor necrosis factor-α response.

In addition, NeoTec4 enhanced the response in IL-4 and globular protein estimates postchallenge and enhanced titers for bovine viral diarrhea and respiratory parainfluenza-3.

Postchallenge serum concentrations of albumin were lower and urea nitrogen concentrations were greater in control calves than in calves fed NeoTec4.

In trial 1b, performance did not differ during the first 28 d when no calves received NeoTec4, but calves receiving NeoTec4 in the second 28 d had greater average daily gain and feed efficiency.

We conclude that supplementation of MR with NeoTec4 alters some immune and inflammatory responses, including increasing titers to bovine viral diarrhea and respiratory parainfluenza-3 vaccinations, reduces scours, reduces medical treatments for clostridium sickness, and improves growth rates and feed efficiency.

14. 健康増進および疾病予防に於けるココナッツ(Cocos nucifera L .: Arecaceae)

Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention.










Coconut, Cocos nucifera L., is a tree that is cultivated for its multiple utilities, mainly for its nutritional and medicinal values.

The various products of coconut include tender coconut water, copra, coconut oil, raw kernel, coconut cake, coconut toddy, coconut shell and wood based products, coconut leaves, coir pith etc.

Its all parts are used in someway or another in the daily life of the people in the traditional coconut growing areas.

It is the unique source of various natural products for the development of medicines against various diseases and also for the development of industrial products.

The parts of its fruit like coconut kernel and tender coconut water have numerous medicinal properties such as antibacterial, antifungal, antiviral, antiparasitic, antidermatophytic, antioxidant, hypoglycemic, hepatoprotective, immunostimulant.

Coconut water and coconut kernel contain microminerals and nutrients, which are essential to human health, and hence coconut is used as food by the peoples in the globe, mainly in the tropical countries.

The coconut palm is, therefore, eulogised as 'Kalpavriksha' (the all giving tree) in Indian classics, and thus the current review describes the facts and phenomena related to its use in health and disease prevention.

15. In Vivo条件で、乾燥ココナッツを原料にして、発酵処理したバージンココナッツオイルの抗有害、抗炎症活性について

In vivo antinociceptive and anti-inflammatory activities of dried and fermented processed virgin coconut oil.

16. フィリピンでは、ココナッツオイルは、閉経前の女性の、有益な脂質プロファイルに関係しています。

Coconut oil is associated with a beneficial lipid profile in pre-menopausal women in the Philippines.











Coconut oil is a common edible oil in many countries, and there is mixed evidence for its effects on lipid profiles and cardiovascular disease risk.

Here we examine the association between coconut oil consumption and lipid profiles in a cohort of 1,839 Filipino women (age 35-69 years) participating in the Cebu Longitudinal Health and Nutrition Survey, a community based study in Metropolitan Cebu.

Coconut oil intake was estimated using the mean of two 24-hour dietary recalls (9.5±8.9 grams).

Lipid profiles were measured in morning plasma samples collected after an overnight fast.

Linear regression models were used to estimate the association between coconut oil intake and each plasma lipid outcome after adjusting for total energy intake, age, body mass index (BMI), number of pregnancies, education, menopausal status, household assets and urban residency.

Dietary coconut oil intake was positively associated with high density lipoprotein cholesterol especially among pre-menopausal women, suggesting that coconut oil intake is associated with beneficial lipid profiles.

Coconut oil consumption was not significantly associated with low density lipoprotein cholesterol or triglyceride values.

The relationship of coconut oil to cholesterol profiles needs further study in populations in which coconut oil consumption is common.

17. ミトコンドリア脂肪酸の酸化障害の治療に関する現状について

Current issues regarding treatment of mitochondrial fatty acid oxidation disorders.

18. 副甲状腺および腸について

The parathyroids and the gut.
















This review discusses gastrointestinal manifestations of parathyroid diseases. Parathyroid hormone is the primary regulator of calcium physiology. Hypoparathyroidism can be idiopathic, hereditary, or secondary to surgery in the neck.

Hyperparathyroidism is usually from adenomas or hyperplasia.

Hypoparathyroidism is associated with steatorrhea that may improve with medium-chain triglycerides, correction of the hypoparathyroidism, or administration of vitamin D. Hyperparathyroidism results in constipation because of reduction in neuromuscular excitability by high calcium levels.

According to old literature, the incidence of peptic ulcer disease (PUD) in patients with hyperparathyroidism is 9% compared with autopsy rates of 4% to 5%.

Any association is difficult to prove today, as hyperparathyroidism is usually mild due to early detection of cases through routine automated measurements of calcium.

In addition, PUD is less prevalent now than before the advent of proton pump inhibitors.

The presence of ulcers or ulcer symptoms may correct in some patients after parathyroidectomy, suggesting an association.

The incidence of pancreatitis in patients with primary hyperparathyroidism ranges from 1.5% to 12% and may be because of the hypercalcemia.

Complicating the issue is secondary hyperparathyroidism in response to hypocalcemia from pancreatitis.

Pancreatitis may improve in some individuals after parathyroidectomy.

Pancreatitis may follow parathyroid surgery because of an acute rise in calcium levels with manipulation of the parathyroid glands or to a blunted response of calcitonin-producing cells from fatigue.

Parathyroid diseases have a few distinct effects on the gut: steatorrhea in hypoparathyroidism, and constipation, PUD, and pancreatitis in hyperparathyroidism.

19. 筋脂質代謝の障害:診断および治療の課題について

Disorders of muscle lipid metabolism: diagnostic and therapeutic challenges.

20. 運動前の中鎖トリグリセリドの摂取は、長鎖のアシル-CoA-デヒドロゲナーゼ欠損マウス由来の骨格筋におけるアシルカルニチンの蓄積を防止する。

Pre-exercise medium-chain triglyceride application prevents acylcarnitine accumulation in skeletal muscle from very-long-chain acyl-CoA-dehydrogenase-deficient mice.

21. ネコにおける食物中鎖トリグリセリドが血漿脂質およびリポタンパク質分布および食物嫌悪に及ぼす影響

Effects of dietary medium-chain triglycerides on plasma lipids and lipoprotein distribution and food aversion in cats.

22. 極長鎖アシル-CoA脱水酵素欠損症(VLCAD)の新しい栄養管理養生法

Novel nutritional management regimen for very long-chain acyl-CoA dehydrogenase deficiency


23. オメガ3脂肪酸と中鎖トリグリセリドに富んだ食事療法による重度の高トリグリセリド血症の治療に成功しました。

Successful treatment of severe hypertriglyceridemia with a formula diet rich in omega-3 fatty acids and medium-chain triglycerides.

24. ラウリン酸とミリスチン酸は、ラットのテストステロン誘導前立腺肥大を防止する。

Lauric acid and myristic acid prevent testosterone induced prostatic hyperplasia in rats.

25. グリコーゲン貯蔵疾患1型:中鎖脂肪酸が代謝制御および成長に関する影響について

Glycogen storage disease type 1: impact of medium-chain triglycerides on metabolic control and growth.

26. 低温と高温条件下で抽出されたココナッツオイルのフェノール依存性抗酸化特性の比較

Comparison of the phenolic-dependent antioxidant properties of coconut oil extracted under cold and hot conditions

27. レクリエーションアスリートの中程度および高強度の運動での、中鎖トリアシルグリセロールの摂取効果について

Effect of ingestion of medium-chain triacylglycerols on moderate- and high-intensity exercise in recreational athletes.

28. ウサギでのTSHレベルおよび体重増加に関して、ココナッツオイルと大豆油の効果比較について

Comparison of the Effects of Coconut Oil and Soyabean Oil on TSH Level and Weight Gain in Rabbits

29. ヴァージンココナッツオイル の化学特性について

Chemical Properties of virgin coconut oil





VCOについて得られた主要なトリアシルグリセロールは、LaLaLa、LaLaM、CLaLa、LaMMおよびCCLa(La、ラウリン酸; C、カプリン酸、M、ミリスチン酸)であった。ヨウ素価は4.47〜8.55の範囲であり、不飽和結合の存在がわずかであることを示している。

鹸化価は250.07〜260.67mgKOH / g油の範囲であった。

低過酸化物価(0.21-0.57 mequiv oxygen / kg)は高い酸化安定性を示し、アニシジン値は0.16〜0.19の範囲であった。



VCO試料(GAE /油100g 7.78-29.18mg)のフェノール含量は、洗練された漂白脱臭(RBD)VCO(6.14mg GAE / 100g油)よりも有意に高かった。



A study on the commercial virgin coconut oil (VCO) available in the Malaysian and Indonesian market was conducted.

The paper reported the chemical characteristics and fatty acid composition of VCO.

There was no significant difference in lauric acid content (46.64-48.03%) among VCO samples.

The major triacylglycerols obtained for the oils were LaLaLa, LaLaM, CLaLa, LaMM and CCLa (La, lauric; C, capric; M, myristic). Iodine value ranged from 4.47 to 8.55, indicative of only few unsaturated bond presence.

Saponification value ranged from 250.07 to 260.67 mg KOH/g oil.

The low peroxide value (0.21-0.57 mequiv oxygen/kg) signified its high oxidative stability, while anisidine value ranged from 0.16 to 0.19.

Free fatty acid content of 0.15-0.25 was fairly low, showing that VCO samples were of good quality.

All chemical compositions were within the limit of Codex standard for edible coconut oil.

Total phenolic contents of VCO samples (7.78-29.18 mg GAE/100 g oil) were significantly higher than refined, bleached and deodorized (RBD) coconut oil (6.14 mg GAE/100 g oil).

These results suggest that VCO is as good as RBD coconut oil in chemical properties with the added benefit of being higher in phenolic content.

30. バージンココナッツオイルの酸化防止能力とフェノール酸について

Antioxidant capacity and phenolic acids of virgin coconut oil.




発酵法で製造されたヴァージンココナッツオイルは、1,1-ジフェニル-2-ピクリルヒドラジルに対して最も強い掃気効果(体内の不要物質や毒性物質を処理する効果)を示し、β-カロテン - リノレエート漂白法に基づく最高の抗酸化作用を示した。

しかし、低温圧搾法で抽出したヴァージンココナッツオイル は、最も高い還元力を示した。


フェノール含有量と掃去活性(r = 0.91)との間、およびフェノール含有量と還元力(r = 0.96)の間には非常に高い相関が見られた。総フェノール酸とβ-カロチン漂白作用との間にも高い相関があった。



The antioxidant properties of virgin coconut oil produced through chilling and fermentation were investigated and compared with refined, bleached and deodorized coconut oil.

Virgin coconut oil showed better antioxidant capacity than refined, bleached and deodorized coconut oil.

The virgin coconut oil produced through the fermentation method had the strongest scavenging effect on 1,1-diphenyl-2-picrylhydrazyl and the highest antioxidant activity based on the beta-carotene-linoleate bleaching method.

However, virgin coconut oil obtained through the chilling method had the highest reducing power.

The major phenolic acids detected were ferulic acid and p-coumaric acid.

Very high correlations were found between the total phenolic content and scavenging activity (r=0.91), and between the total phenolic content and reducing power (r=0.96). There was also a high correlation between total phenolic acids and beta-carotene bleaching activity.

The study indicated that the contribution of antioxidant capacity in virgin coconut oil could be due to phenolic compounds.

31. 栄養失調のラットで、糖代謝酵素のmRNAレベルに関する中鎖トリアシルグリセロールの摂取効果について

Effects of dietary medium-chain triacylglycerol on mRNA level of gluconeogenic enzymes in malnourished rats.

32. 口腔栄養療法は、乳び胸治療に効果的か? 症例報告。

Is oral nutritional therapy effective for the treatment of chylothorax? A case report.

33. マレーシア、ケランタン州のタンパット地区での妊娠中の漢方薬の使用と周産期死亡率の推移

The use of herbal medicines during pregnancy and perinatal mortality in Tumpat District, Kelantan, Malaysia.

周産期死亡率: 出産総数に対する後期胎児死亡の割合は後期胎児死亡率と呼ばれる。出生数に対する後期胎児死亡数の比率は後期胎児死亡比 と呼ばれている。 胎児死亡率は、同一年次における出産数1000に対する既知の子宮内死亡数の比率であり、一方、胎児死亡比 は出生数1000に対する子宮内死亡数の比率である。これらの指標は、早期子宮内死亡がしばしば観察されないか、あるいは気付かれないままでいることがあるため、実際の子宮内死亡率を大幅に過少評価している。子宮内死亡を計測するよりよい方法として、子宮内死亡表 5が作成される。これは生命表(432参照)の一つの応用で、妊娠期間に基づいて作成される。 周産期死亡率 は後期胎児死亡数と出生数の和に対する周産期死亡数の比率である。

34. Sprague-Dawleyラットにおけるテストステロン誘発での前立腺肥厚に対するココナッツオイルの効果について

Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats.[volume]+AND+995[page]+AND+2007[pdat]&cmd=detailssearch

35. カルニチン輸送の障害およびカルニチンサイクル

Disorders of carnitine transport and the carnitine cycle.



このカルニチンサイクルを構成する酵素の欠損症として,カルニチンパルミトイルトランスェラーゼ1(CPT1)欠損症,カルニチンパルミトイルトランスフェラーゼ2 (CPT2)欠損症, カルニチン/アシルカルニチントランスロカーゼ(CACT)欠損症が挙げられる.それぞれの酵素の先天的な欠損により,長鎖脂肪酸のミトコンドリア内への転送が障害され,脂肪酸代謝が十分行われなくなり,その結果エネルギー産生の低下を引き起こす.いずれも常染色体劣性遺伝の疾患である.

36. 1500グラム以下の乳児の体重増加を増強するためのヴァージンココナッツオイル の使用に関する無作為化試験。 予備的結果

A randomized controlled trial on the use of virgin coconut oil in augmenting weight gain among infants weighing 1500 grams or less; preliminary results







出生時体重/ 1500gを有する新生児;少なくとも50ml / kg /日の経腸栄養を許容し、インフォームドコンセントを含むことができる。



VCOを0.5ml / ozで処理群に添加して摂取した。

結果は治療する意図で分析した。 p-値0.05を統計学的に有意とみなした